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Uncoupling of G proteins to the C-terminal st-mPRα mutant was also accompanied with a predicted decrease in ligand binding affinity for the receptor ( Fig. Localization, orientation, and functional domains of the mPRαs, . A and B, Immunocytochemical localization of st-mPRα (Aa) and hu-mPRα (Ba) on external surface of plasma membranes of transfected cells with specific N-terminal directed antibodies. Ab and Bb, Blocked with peptide antigens; Ac and Bc, lack of immunoreaction with nontransfected cells; Bd, lack of immunoreaction with nonpermeabilized cell using C-terminal antibody.
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